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Celebrex capsules contain the active ingredient celecoxib, which is a type of drug known as a non-steroidal anti-inflammatory drug.
Celebrex has been found to reduce the number of colorectal polyps (growths in the wall of the lower intestine and rectum) in people who suffer from the condition called familial adenomatous polyposis (FAP), an inherited tendency to develop large numbers of colorectal polyps that eventually become cancerous.
Celebrex is prescribed for acute pain, menstrual cramps, and the pain and inflammation of osteoarthritis and rheumatoid arthritis. It is a member of a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) called COX-2 inhibitors. Like older NSAIDs such as Motrin and Naprosyn, Celebrex is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Therefore, Celebrex may be less likely to cause the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs.
Cyclo-oxygenase does not only produce prostaglandins that cause inflammation. It produces prostaglandins that have useful roles in the body. There are two different forms of cyclo-oxygenase, COX-1 and COX-2. COX-2 is the form that produces prostaglandins that cause inflammation. COX-1 does not produce inflammatory prostaglandins, but does produce others that have useful effects, including some that are involved in maintaining a healthy stomach and intestinal lining.
NSAIDs work by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases. These prostaglandins cause pain, swelling and inflammation. Because NSAIDs block the production of these prostaglandins, they are effective at relieving pain and inflammation.
Traditional NSAIDs, such as ibuprofen or diclofenac, block the action of both COX-1 and COX-2, and this is why they can sometimes cause side effects such as stomach irritation and peptic ulcers. Celecoxib belongs to a new generation of NSAIDs that selectively block the action of COX-2. This means that it stops the production of inflammatory prostaglandins, without stopping the production of prostaglandins that protect the stomach and intestines. It therefore reduces pain and inflammation, but is less likely than traditional NSAIDs to cause side effects on the stomach and intestines.
Celebrex is prescribed for the treatment of:
- Rheumatoid arthritis;
Celebrex Side Effects
Celebrex side effects that you should report to your health care professional or doctor as soon as possible:
- Abdominal pain;
- Blurred vision;
- Difficulty in sleeping;
- Disturbances of the gut such as indigestion, diarrhoea, constipation, nausea, vomiting, flatulence or abdominal pain;
- Heart attack or stroke;
- High blood pressure;
- Increased potassium level in the blood;
- Inflammation of the lining of the nose causing a blocked or runny nose;
- Inflammation of the sinuses;
- Inflammation of the throat;
- Liver, kidney or blood disorders;
- Pins and needles;
- Respiratory infection;
- Retention of water in the body tissues swelling, particularly of the legs and ankles;
- Sensation of ringing or other noise in the ears;
- Shortness of breath;
- Sinus inflammation;
- Skin reactions such as rash;
- Ulceration or bleeding of the stomach or intestines;
The following dosages are typically cut in half for people with moderate liver problems.
The recommended daily dose is 200 mg, taken as a single dose or in 100-mg doses twice a day.
Acute Pain and Menstrual Cramps
The recommended starting dose is 400 mg, followed by an additional 200 mg if needed on the first day.
On subsequent days, the recommended dosage is 200 mg twice a day.
The recommended dose is 100 to 200 mg twice a day.
Familial Adenomatous Polyposis
The recommended dose is 400 mg twice a day with food.